Ubuntu
Gary's written a reflection on using Ubuntu. It's kind of reassuring.
I've been using Ubuntu in a virtual machine for a while for some projects I've been working on. I kind of like it (although, I have switched to using Xubuntu, as it has a lower resource overhead).
There are still a few areas where the open source community lacks strong software. These are .Net development (nothing comes close to Visual Studio and Resharper), and music.
There's one DAW solution, but I tend to use Ableton Live, which is a bit of a hybrid, and I've not really seen else like it. That, and Guitar Rig. There is FreeAmp, but Guitar Rig is soooo amazing, I don't know how anyone else could do that.
There are some components out there that could be put together to arrange something ableton like, but, as always, it's time, and tweaking, and it's time i could actually spend playing guitar.
Yeah, so use ubuntu if you don't want to do music on your pc.